Essendon's injury curse has continued in the post-Brad Scott era, with Archie May dislocating his shoulder in the Bombers' 30-point loss to West Coast at a windy Optus Stadium.

On a day when Perth was hit by a once-in-a-five-year storm before conditions calmed during the game, West Coast kicked eight unanswered goals either side of halftime to soar to a 12.13 (85) to 8.7 (55) win in front of 37,623 fans.

The match was Essendon's first since sacking Scott during the week, and they fronted up against the Eagles nursing a 16-player injury list.

That became 17 in the first quarter when May dislocated his right shoulder after being cleaned up by teammate Nate Caddy in a marking contest.

Apart from brief patches and some late junk goals, Essendon barely troubled West Coast.

Even the Bombers' 44-23 dominance at the clearances didn't translate to any sort of authority.

The result improved West Coast's record to 4-8, already a marked improvement on last year's one-win wooden-spoon campaign.

Essendon (1-11) are in grave danger of collecting this year's spoon.

Harley Reid (24 disposals, one goal), Tim Kelly (28 disposals, 554m gained), Milan Murdock (three goals, 19 disposals) and Jake Waterman (three goals, nine marks) played important roles for the Eagles.

But best-on-ground honours went to Reuben Ginbey, who was a star in defence and kept Caddy goalless for three quarters.

The Bombers forward kicked two goals late in the game - one when Ginbey was off the ground - but had no other influence on the contest.

For Essendon, Archie Roberts (30 disposals, 570m gained), Zach Merrett (28 disposals, one goal) and Sullivan Robey (nine clearances, 19 disposals) found plenty of the ball in a losing cause.

Interim Essendon coach Dean Solomon pulled a surprise move by playing Ben McKay at full-forward, but he was non-existent early as West Coast registered the first 10 inside 50s of the match while kicking with the breeze.

The Eagles led 17-1 by quarter-time, but Essendon made the most of the strong breeze early in the second term and even had several opportunities to snatch the lead.

Their missed chances proved costly, with West Coast's counter-punch netting three important goals as the Eagles entered halftime with a 20-point buffer.

The highlight of the second quarter belonged to Reid, who sold a dummy and shook off two tacklers while surrounded by players before snapping truly to send the crowd wild.

West Coast iced the game with a dominant five-goal burst to start the third quarter.

Murdock got a free-kick in attack even before the third quarter officially started after being pushed to the ground by Jaxon Prior.

That goal was followed by another to Bailey Williams - this time for a ruck infringement.

And when Willem Duursma's 50m set show was followed by goals to Waterman and Tom McCarthy, the margin was a whopping 53 points.